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KMID : 0352119950110020167
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Journal of Kyung Hee University
1995 Volume.11 No. 2 p.167 ~ p.174
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The Changes in Serum Electrolytes with Doses of Mannitol Administration in Neurosurgical Patients.
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Abstract
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To reduce intracranial pressure and to decrease brain bulk, mannitol, an osmotic diuretic was used in neurosurgical patients. Randomly selected 40 patients were divided into two groups, 20 subjects each. 25% mannitol was administered with the
dose
of
1.0g/kg for group 1(n=20) and 2.0g/kg for group 2(n=20). To observe changes in serum electrolytes, blood samplings were taken for five times in both groups. First sampling was taken just prior to mannitol infusion; second, at the completion of
mannitol
infusion; third, fourth and fifth, at 15 minutes, 30 minutes and 60 minutes after mannitol infusion, respectively.
Serum potassium level in group 1 was decreased from 3.40mEq/L to 3 02mEq/L at most in 15 minutes after mannitol infusion (p<0.05), whereas it was increased in group 2 from 3.46mEq/L to 4.06mEq/L at most in 15 minutes after mannitol infusion
(p<0.01). As
for serum sodium, it was decreased from 130.8mEq/L to 126.3mEq/L in group 1 (p<0.01) and from 131.9mEq/L to 124.7mEq/L in group 2 (p<0.01) at the completion of mannitol infusion, Serum bicarbonate level in group 2 was decreased to 21.02 mEq/L
(p<0.05)
and 20.75 mEq/L (p<0.01) at most in 15 and 30 minutes after mannitol infusion as compared to control value (22.92mEq/L), respectively.
The purpose of this study was to analyze the effects of mannitol infusion on serum electrolytes in neurosurgical patients, emphasizing the differences between the low- and high-dose mannitol. We were able to conclude that the high-dose mannitol
may
cause an increase in serum potassium, though transient and it should be used with much caution when required, especially in patients with high risk of developing hyperkalemia.
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KEYWORD
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